After 14 years of peace in the Ohu Mountains, a strange, horrible monster invaded and overtook Gajou, the dog paradise. During the battle, the leader Gin sent his mate, Sakura, off with one of his commanders, Smith, to keep their unborn pups safe.

Six months later, a young Akita pup that looks just like Gin met GB, an English setter and a slave of a rogue boss dog named Nero. The pup tried to save one of GB's friends from a farm's guard dog, but all three ultimately are saved by Smith, who now has lost his right foreleg. Smith recognizes the pup and is led to Sakura, who is deathly ill. Soon after Smith's arrival, Sakura dies. With his father missing and his mother dead, GB and Smith take the pup in; GB names the pup Weed, due to his tenacious spirit.

The group has several adventures on their way back to the Ohu Mountains, and find more allies as they battle and defeat the monster and rescue Gin.Weed is the sequel story to Ginga Nagareboshi Gin, Weed is the son of the two main dogs in that story. Yoshihiro Takahashi is the author who is famous for writing dog stories. The still-running series has released 45 tankoubon so far and is published in Japan by Nihon Bungeisha and was published in America by Comics One until they disappeared. Takahashi also wrote some side-stories about Weed and some of the other dogs in the story.

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